From Honey Urine to Modern Medicine: Understanding Diabetes
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For thousands of years, physicians watched patients waste away as their bodies lost sugar through their urine — but no one understood why. Treatments ranged from starvation diets and extreme restrictions to opium, tobacco, and questionable “cures.”
Then in 1921, everything changed.
The discovery of insulin transformed diabetes from a fatal disease into a manageable one — but the story of how we got there is filled with desperate experiments, ethical questions, and the lives of people who pushed medicine forward.
📚 References
- Ahmed, A. M. (2002). History of diabetes mellitus. Saudi Medical Journal, 23(4), 373–378. https://pubmed.ncbi.nlm.nih.gov/11953758/
- American Diabetes Association. (2021). The history of the wonderful thing we call insulin. https://diabetes.org/blog/history-wonderful-thing-we-call-insulin
- Cleveland Clinic. (2024). Diabetes: What it is, causes, symptoms, treatment & types. https://my.clevelandclinic.org/health/diseases/7104-diabetes
- Karamanou, M., Protogerou, A., Tsoucalas, G., Androutsos, G., & Poulakou-Rebelakou, E. (2016). Milestones in the history of diabetes mellitus: The main contributors. World Journal of Diabetes, 7(1), 1–7. https://doi.org/10.4239/wjd.v7.i1.1
- March, C. A., Libman, I. M., Becker, D. J., & Levitsky, L. L. (2022). From antiquity to modern times: A history of diabetes mellitus and its treatments. Hormone Research in Paediatrics, 95(6), 593–607. https://doi.org/10.1159/000526441
- National Center for Biotechnology Information. (n.d.). John Rollo. https://en.wikipedia.org/wiki/John_Rollo
- National Center for Biotechnology Information. (n.d.). Arnaldo Cantani. https://en.wikipedia.org/wiki/Arnaldo_Cantani
- Rockefeller University Center for Clinical and Translational Science. (n.d.). Dietary therapy for diabetes. Rockefeller University. https://centennial.rucares.org/index.php?page=Dietary_Therapy_Diabetes
- Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop, P. H., Handelsman, Y., Insel, R. A., Mathieu, C., McElvaine, A. T., Palmer, J. P., Pugliese, A., Schatz, D. A., Sosenko, J. M., Wilding, J. P. H., & Ratner, R. E. (2017). Differentiation of diabetes by pathophysiology, natural history, and prognosis. Diabetes Care, 40(10), 1302–1309. https://doi.org/10.2337/dc16-2046
- World Health Organization. (n.d.). Diabetes mellitus and history of diabetes care. World Health Organization. https://www.who.int/
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