Ep. 135 “Olfactory Receptors Beyond the Nose” Featuring Dr. Marco Orecchioni
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Ep. 135 “Olfactory Receptors Beyond the Nose” Featuring Dr. Marco Orecchioni
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Dr. Marco Orecchioni is an Assistant Professor at Augusta University. He discusses how olfactory receptors — best known for detecting smells — also function in innate immune cells such as macrophages, where they help sense chemical cues in the tissue environment. He highlights how these receptors regulate inflammation, metabolism, and immune cell behavior in diseases such as atherosclerosis, and explores their potential as novel therapeutic targets.
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Origins of Tumor Macrophages – Tumor-associated myeloid cells arise from distinct circulating monocyte clones with pre-programmed differentiation fates.
DDX6 Restrains Tumor Immunity – DDX6 suppresses dsRNA-driven innate immunity by limiting RNA editing.
Antibody-Directed Xenophagy – TRIM21 directs antibody-bound pathogens into a newly identified autophagy pathway that promotes intracellular pathogen clearance.
RNA Warfare in Plant Immunity – A fungal long non-coding RNA suppresses rice immunity by sequestering a host microRNA.
Image courtesy of Dr. Marco Orecchioni.
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