This week, we discuss the latest challenges facing US science outlined by president of the US National Academy of Sciences Marcia McNutt in her outgoing address as well as the unique chemistry underpinning wool's incredible properties with Neil Withers and Rebecca Trager.

Marcia McNutt gave her final address as president of the US National Academy of Sciences earlier this month, warning of turmoil for science in the wake of further proposals by the White House to restrict funding. We discuss highlights from the event.

And, how does the chemical composition of wool contribute to its material properties? We explore this staple fabric and its uses beyond clothing.

This week, we look back at how far click chemistry has come in the last 25 years and discuss the strange bonding behaviour of some of the largest elements on the periodic table with Mason Wakley and Frances Briggs.

It started as a review paper in 2001 that has since been cited almost 20,000 times, becoming one of the most influential chemistry papers ever written. Click chemistry has revolutionised the way we build molecules. But what defines a click reaction, and what does the future hold?

And, new research has revealed experimental evidence of how covalent bonding affects the 5f orbital in early actinides. We discuss the challenges of studying these elements.

This week, we discuss the latest milestone in quantum computational modelling and reveal the common laboratory item causing strange readings in microplastics research with Frankie Macpherson and Patrick Walter.

A new hybrid workflow involving two IBM quantum computers and two powerful supercomputers has allowed researchers to model a protein–ligand system containing up to a record 12,635 atoms. What does this mean for the future of quantum computing?

And, a recent study has found an unsuspecting source of contamination in microplastics research, distorting measurements of atmospheric pollution. We discuss the underlying cause.