Can molecular monitoring help clinicians intervene earlier to extend the benefit of first-line therapy?

In this episode of CHM Conversations, Dr. Neil Iyengar, Dr. Manali Bhave, and Dr. Reshma Mahtani discuss overcoming resistance in HR+ mBC.

The conversation focuses on the SERENA-6 trial and the strategy of using serial ctDNA monitoring to catch ESR1 mutations before radiographic progression. Dr. Neil Iyengar, Dr. Manali Bhave, and Dr. Reshma Mahtani break down the practicalities of sequencing endocrine therapies and other targeted therapies, and specifically how a proactive switch to camizestrant may delay the transition to chemotherapy.

Beyond the data, the clinicians address real-world challenges—from navigating insurance and workflow logistics to managing the emotional impact of "molecular progression" and side effects like

photopsia.

An essential update for oncology clinicians looking to optimize treatment sequencing and patient quality of life.

🎧 Watch more expert-led oncology conversations from CHM Conversations.

#BreastCancer #MetastaticBreastCancer #HRPositive #HER2Negative #ESR1 #Camizestrant #SERENA6 #OralSERD #ctDNA #LiquidBiopsy #PrecisionOncology #CDK46 #EndocrineTherapy #PIK3CA #TargetedTherapy #MedicalOncology #BreastOncology #CommunityHealthMedia

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Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.

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