Episode 12. The Chemical Sensitizer Wake-Up Call
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Episode 12. The Chemical Sensitizer Wake-Up Call
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RESOURCES FROM THIS EPISODE
McKnelly, K.J.; Sokol, W.; Nowick, J.S. (2019) Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU. https://pubs.acs.org/doi/abs/10.1021/acs.joc.9b03280
Graham, J.C.; Trejo-Martin, A.; Chilton, M.L.; Kostal, J.; Bercu, J.; Beutner, G.L.; Bruen, U.S.; Dolan, D.G.; Gomez, S.; Hillegass, J.; Nicolette, J.; Schmitz, M. (2022) An Evaluation of the Occupational Health Hazards of Peptide Couplers. https://pubs.acs.org/doi/10.1021/acs.chemrestox.2c00031
Miralles, J. C., Negro, J. M., Alonso, J. M., García, M., Sánchez-Gascón, F., & Soriano, J. (2003). Occupational rhinitis and bronchial asthma due to TBTU and HBTU sensitization. https://pubmed.ncbi.nlm.nih.gov/12968399/
Hannu, T., Alanko, K., & Keskinen, H. (2006). Anaphylaxis and allergic contact urticaria from occupational airborne exposure to HBTU. https://pubmed.ncbi.nlm.nih.gov/16861336/
OSHA HazComm (29 CFR 1910.1200) https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1200
OSHA Laboratory Standard (29 CFR 1910.1450) https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1450
OSHA Permissible Exposure Limits - Annotated Tables https://www.osha.gov/annotated-pels
OSHA Respiratory Protection Standard (29 CFR 1910.134) https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.134
OSHA General Duty Clause (OSH Act of 1970 Section 5) https://www.osha.gov/laws-regs/oshact/section5-duties
ACS Webinar: Bonding with Caution: Understanding the Hazards of Peptide Couplers https://www.acs.org/acs-webinars/library/hazards-of-peptide-couplers.html
LET US KNOW!
Have you worked through challenges of working with chemical sensitizers with a lab group?
If not, has this episode inspired you to start asking more questions about chemical sensitizer use in your labs?
HOW TO LET US KNOW!
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o Leave a comment on this episode
ElevenLabs was used to create the AI-generated voice in the Disclaimer at the end of this episode. For more information, visit https://elevenlabs.io/app/home