The Immune team discusses a paper describing the negative effects of old B cells on T cells and longevity and a snippet on an interesting vaccine approach to promote competition between gut commensals.

Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Vaccine enhanced competition of gut bacteria (Science 2025)
• B cells drive immunosenescence and aging (Sci Immunol 2026)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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A former anti-vax mom talks about going down the rabbit hole, her mindset shift, the importance of doctors who are willing to talk with patients about vaccines, and why she is now a vaccine advocate.

Host: Cindy Leifer

Guest: Ellen Mary Woods

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• MicrobeTV Discord Server
• A shot at life foundation
• Voices for Vaccines information and advocacy
• What the iPhone bendgate can teach us about vaccine hesitancy
• Tips for conversations with vaccine hesitant people
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Information on this podcast should not be construed as medical advice.

Gabrielle Rizzuto from Memorial Sloan Kettering Cancer Center discusses her work on the curious immunology of pregnancy and how a woman tolerates a genetically different baby but quickly rejects a mismatched organ donation.

Host: Cindy Leifer

Guest: Gabrielle Rizzuto

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• MicrobeTV Discord Server
• Rizzuto lab at MSKCC
• Tolerance at the fetal-maternal interface (Nature, 2022)
• The paradox of fetal-maternal tolerance (J Exp Med, 2022)
• Spatially resolved timeline of fetal-maternal interface (Nature, 2023)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Information on this podcast should not be construed as medical advice.

Immune discusses how tattoo ink accumulates in lymph nodes, promotes inflammation and influences response to two different vaccines.

Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker

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• MicrobeTV Discord Server
• IL-9, CAR T cells and anti-tumor CD8 cells
• Tattoo ink, inflammation and vaccines
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Information on this podcast should not be construed as medical advice.

Anna Beaudin from University of Utah talks about the key thread of her career, development, and how that influences her research on the events happening during critical prenatal windows shapes everything from the developing immune system to hearing loss.

Host: Cindy Leifer

Guest: Anna Beaudin

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• MicrobeTV Discord Server
• Beaudin lab at University of Utah
• PhD work on metabolism and development
• Postdoc work on hematopoietic stem cells
• Maternal inflammation and hematopoietic stem cell development
• Prenatal inflammation effect on postnatal immunity
• Early life inflammation and hearing loss
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Information on this podcast should not be construed as medical advice.

Host: Cindy Leifer

Guest: Leslie Berg

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• MicrobeTV Discord Server
• Berg lab at University of Colorado Anschutz
• TCR thresholds and ITK (PNAS)
• Review on TCR signaling (Nat Immunol)
• Generation of TCR transgenic mice (Mol Cell Bio)
• T cell negative selection in TCR transgenic mice (Nature)
• Thymic exit of mature T cells in TCR transgenic mice (Cell)
• AAI past president Berg information
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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The whole Immune gang gathers with special guests Gretchen Diehl and Shruti Naik at The Incubator with an audience to celebrate the 100th episode.

Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker

Guests: Gretchen Diehl and Shruti Naik

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• MicrobeTV Discord Server
• Diehl: Gut microbe-specific T cell development (Nature 2021)
• Diehl: Bacteria-induced IL-1 is gut protective (Gut Microbes 2022)
• Diehl: Microbiota, macrophages, IL10, and colitis (Gut Microbes 2022)
• Diehl: E. coli-activated circuit restrains gut inflammation (Cell Rep 2025)
• Naik: Commensals control skin inflammation (Science 2012)
• Naik: IL-17 and hypoxic stress during skin repair (Science 2022)
• Naik: Human psoriasis and spatial transcriptomics (Sci Immunol 2023)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.

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Information on this podcast should not be construed as medical advice.

David Schatz talks about his discovery of Rag genes that are critical for antigen receptor development and how that discovery depended on taking high risks and using approaches that everyone thought could never work.

Host: Cindy Leifer

Guest: David Schatz

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• MicrobeTV Discord Server
• Transfer of recombinase activity in non-lymphoid cells (Cell 1988)
• Identification of the RAG-1 gene (Cell 1989)
• Evolution of a recombinase (Semin Immunol 2004)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.