In today's episode, Haylie Pomroy sits down with Dr. David Systrom, a pulmonary and critical care physician at Mass General Brigham and Assistant Professor at Harvard Medical School, to explore the science behind exercise intolerance in ME/CFS and long COVID.

Dr. Systrom breaks down the invasive cardiopulmonary exercise test (CPET) and what it reveals about blood flow, oxygen extraction, and mitochondrial dysfunction in patients who have been told their tests are normal. He explains why dysautonomia, small fiber neuropathy, and acquired mitochondrial dysfunction may be driving the fatigue, post-exertional malaise, and wide-ranging symptoms these patients experience every day.

He also shares details on two active clinical trials at Brigham and Women's Hospital, including the LYFT trial testing low-dose naltrexone, Pyridostigmine (Mestinon), and the combination of both, as well as a muscle biopsy study designed to understand the role of the mitochondrion in post-exertional malaise.

If you or someone you love has been dismissed, misdiagnosed, or left without answers, tune in to Fast Metabolism Matters

Dr. David Systrom is a physician at Brigham and Women's Hospital. He is also an assistant professor of medicine at Harvard Medical School. He received his medical degree from Dartmouth Medical School. He then completed a residency in internal medicine at Emory University Hospital, followed by a fellowship in internal medicine at Massachusetts General Hospital. He is board-certified in internal medicine and pulmonary disease. An active investigator and director of the Massachusetts General Hospital Cardiopulmonary laboratory, Dr. Systrom regularly publishes research examining pulmonary hypertension, pulmonary vascular disease, right heart failure, and thromboembolic disease. He has authored over 130 peer-reviewed publications, has received funding from the National Institutes of Health and the American Heart Association, and has been named to the annual list of the Best Doctors in America. Dr. Systrom is a member of the American Thoracic Society, the American Heart Association and the American Physiological Society. He has special expertise in the pathophysiology of exercise intolerance in ME/CFS and Long Covid and is conducting clinical trials investigating the same

Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.

Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com

Instagram: https://www.instagram.com/hayliepomroy

Facebook: https://www.facebook.com/hayliepomroy

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In today's episode, Haylie Pomroy sits down with Dr. Theoharis Theoharides — Professor of Clinical Immunology and Executive Director of the Center for Excellence in Neuroinflammation Research — to dig into a topic that's finally getting the attention it deserves: multiple chemical sensitivity (MCS) and its deep connection to mast cell activation.

Dr. Theoharides explains what actually happens in the immune system when the body is exposed to everyday chemicals — from perfume and jet fuel to formaldehyde in clothing and mycotoxins in food. He walks through the biology of mast cells, why stress dramatically lowers your chemical reaction threshold, and why so many patients go undiagnosed or are dismissed as "just sensitive."

Haylie brings her own personal experience with chemical sensitivity and autoimmune disease to the conversation, making this one of the most candid and clinically rich discussions we've had on the show. Whether you've been told your symptoms are in your head, or you've quietly suspected that your environment is making you sick, this episode is for you.

Tune in to Fast Metabolism Matters — and finally get the science to back up what your body has been telling you all along.

Dr. Theoharis Theoharides is a Professor, Vice Chair of Clinical Immunology, and Director at the Institute for Neuro-Immune Medicine-Clearwater, an Adjunct Professor of Immunology at Tufts School of Medicine, where he was a Professor of Pharmacology and Internal Medicine, and also the Director of Molecular Immunopharmacology & Drug Discovery, and Clinical Pharmacologist at the Massachusetts Drug Formulary Commission (1983-2022). He received his BA, MS, MPhil, PhD, and MD degrees and the Winternitz Price in Pathology from Yale University and received a Certificate in Global Leadership from Tufts Fletcher School of Law and Diplomacy and a Fellowship at Harvard Kennedy School of Government. He trained in internal medicine at New England Medical Center, which awarded him the Oliver Smith Award, "recognizing excellence, compassion, and service." Dr. Theoharides has 485 publications (46,491 citations; h-index 106), placing him in the world's top 2% of most cited authors, and he was rated the worldwide expert on mast cells by Expertscape. He was inducted into the Alpha Omega Alpha National Medical Honor Society, the Rare Diseases Hall of Fame, and the World Academy of Sciences.

Website: https://www.drtheoharides.com

LinkedIn: linkedin.com/in/theoharis-theoharides-ms-phd-md-faaaai-67123735

Instagram: https://www.instagram.com/dr.theoharides/

Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.

Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com

Instagram: https://www.instagram.com/hayliepomroy

Facebook: https://www.facebook.com/hayliepomroy

YouTube: https://www.youtube.com/@hayliepomroy/videos

LinkedIn: https://www.linkedin.com/in/hayliepomroy/

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In today's episode, Haylie Pomroy sits down with Dr. Nancy Klimas, Director of the Institute for Neuro-Immune Medicine at Nova Southeastern University, to map out a practical, clinically grounded starting point for anyone navigating post-viral illness — whether that's long COVID, ME/CFS, post-viral chronic fatigue, or a diagnosis they're still trying to name.

Dr. Klimas walks through how to become a skilled historian of your own health, outlines the three most critical areas to address first: sleep, dysautonomia and the autonomic nervous system, and bioenergetics — the mitochondrial and nutritional foundations that drive energy, inflammation, and immune function.

Perhaps most powerfully, Dr. Klimas closes with a message she gives from every stage and every microphone: these are curable illnesses, not just manageable ones — and the science is closer than most patients have been told.

If you or someone you love is losing traction and can't figure out why, this episode is your roadmap — tune in to Fast Metabolism Matters.

Dr. Nancy Klimas, a clinical immunologist by training, is the director of the Institute for Neuro-Immune Medicine, who has allotted her life to helping other people find cures for their complex illnesses that were once considered helpless. She works with her fellow medical experts in researching and analyzing the deeper causes of such diseases, particularly on the neuro-immunity side, to provide the best option suited for every single case or story they handle.

LinkedIn: https://www.linkedin.com/in/nancy-klimas-49255178/

Instagram: https://instagram.com/nancyklimas

Twitter: https://x.com/ngklimas?s=20

Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.

Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com

Instagram: https://www.instagram.com/hayliepomroy

Facebook: https://www.facebook.com/hayliepomroy

YouTube: https://www.youtube.com/@hayliepomroy/videos

LinkedIn: https://www.linkedin.com/in/hayliepomroy/

X: https://x.com/hayliepomroy

Each patient is unique, and effective care requires a comprehensive, 360-degree perspective.

In this episode, Dr. Irina Rozenfeld joins Haylie Pomroy to share the right formula for delivering personalized, patient-centered care for individuals with chronic illness. They emphasize the importance of a strong therapeutic relationship as a foundation for effective treatment and long-term outcomes, and why each patient deserves empathy.

Dr. Rozenfeld further explains how clinicians can help patients bridge knowledge gaps, the role of healthcare practitioners in supporting ongoing healing and wellness, and why combining patient education with expert guidance is essential for optimal care.

Learn how empathy and personalized care strategies can transform chronic illness outcomes—tune in to Fast Metabolism Matters.

Irina Rozenfeld, DNP, MSHS, APRN, ANP-BC, is a Board-Certified Nurse Practitioner committed to the health of her patients. Irina emphasizes patient-practitioner relationships, critical thinking, and patient education to develop an optimal treatment plan and achieve sustainable results. She obtained her Bachelor's of Science degree from Nova Southeastern University and a Master's of Science in Nursing Studies from Florida International University. Additionally, she has obtained a Master's degree in Integrative Medicine from George Washington University School of Medicine and a Doctoral degree at the University of North Florida. Before joining the INIM, Irina worked for more than twenty years as a physician assistant in Russia. After relocating to Florida, she worked as a Clinical Research Nurse at Nova Southeastern University. Irina obtained an international certification as a Clinical Research Professional and has been involved in research in many roles. Irina teaches at Nova Southeastern University College of Nursing as an adjunct faculty.

Facebook: https://www.facebook.com/irina.rozenfeld.1

LinkedIn: https://www.linkedin.com/in/irina-rozenfeld-413a4028/

Instagram: https://www.instagram.com/irina.rozenfeld.1/

Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.

Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com

Instagram: https://www.instagram.com/hayliepomroy

Facebook: https://www.facebook.com/hayliepomroy

YouTube: https://www.youtube.com/@hayliepomroy/videos

LinkedIn: https://www.linkedin.com/in/hayliepomroy/

X: https://x.com/hayliepomroy

In today's episode, Haylie Pomroy shares a conversation with Dr. Nancy Klimas, Director of the Institute for Neuro-Immune Medicine, focusing on long COVID—particularly the role of the spike protein in persistent symptoms following SARS-CoV-2 infection.

Dr. Klimas provides a clinical definition of long COVID and neuroinflammation, outlines the mechanisms behind post-exertional malaise, and explains the significant overlap in symptom presentation between long COVID and ME/CFS. She also discusses the observed rise in postural orthostatic tachycardia syndrome (POTS) following COVID-19 and offers guidance on how patients can effectively communicate with their healthcare providers about their symptoms.

In addition, she highlights ongoing monoclonal antibody trials at the institute and how these therapies may help target and clear persistent spike protein from the body.

Understand why symptoms can persist after COVID-19 and what may be driving them—tune in to Fast Metabolism Matters.

Dr. Nancy Klimas, a clinical immunologist by training, is the director of the Institute for Neuro-Immune Medicine, who has allotted her life to helping other people find cures for their complex illnesses that were once considered helpless. She works with her fellow medical experts in researching and analyzing the deeper causes of such diseases, particularly on the neuro-immunity side, to provide the best option suited for every single case or story they handle.

LinkedIn: https://www.linkedin.com/in/nancy-klimas-49255178/

Instagram: https://instagram.com/nancyklimas

Twitter: https://x.com/ngklimas?s=20

Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.

Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com

Instagram: https://www.instagram.com/hayliepomroy

Facebook: https://www.facebook.com/hayliepomroy

YouTube: https://www.youtube.com/@hayliepomroy/videos

LinkedIn: https://www.linkedin.com/in/hayliepomroy/

X: https://x.com/hayliepomroy

In this episode, Dr. Andrew Campbell, Medical Advisor for MyMycoLab, joins Haylie Pomroy to discuss how mold exposure can affect the body both physically and physiologically, including clinical observations in women experiencing symptoms associated with breast implant illness.

Dr. Campbell also explores how mold and mycotoxins function biologically, why it is important for physicians to expand their understanding of how these exposures may contribute to chronic disease and neurological conditions, and how environmental toxicity can increase the likelihood of mycotoxin exposure and accumulation.

He further explains how urine and serum testing for mycotoxins can support diagnosis and treatment planning, outlines how MyMycoLab testing works, and answers questions from the community about home testing, brain fog, and other related concerns.

Catch their conversation about When Mold Becomes a Health Problem here on the Fast Metabolism Matters podcast.

Dr. Andrew Campbell is a Medical Clinician, Director, Officer, Advisor, and Medical Consultant, also Editor-in-Chief of several journals and research studies, and was recently selected as Top Medical Consultant of the Year for 2020 by the International Association of Top Professionals (IAOTP) for his outstanding leadership, dedication, and commitment to the healthcare profession. With over 45 years of professional experience as a renowned Medical Clinician, Dr. Campbell has certainly proven himself as an expert in the field of integrative health and traditional medicine. Dr. Campbell is a dynamic, results-driven leader who has demonstrated success by treating the most complex patients and having extensive experience with testing for molds and mycotoxins from environmental and toxic exposures. He is fluent in Arabic, Hungarian, French, Spanish and English. He has also effectively worked alongside medical professionals from other cultures in Central and South America, Western and Eastern Europe, and the Middle East.

Website: https://andrewcampbellmd.com/

LinkedIn: https://www.linkedin.com/in/andrewwcampbell-md/

YouTube: https://www.youtube.com/c/MyMycoLabLLC

Learn more about MyMycoLab: https://mymycolab.com/

Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.

Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com

Instagram: https://www.instagram.com/hayliepomroy

Facebook: https://www.facebook.com/hayliepomroy

YouTube: https://www.youtube.com/@hayliepomroy/videos

LinkedIn: https://www.linkedin.com/in/hayliepomroy/

X: https://x.com/hayliepomroy

In today's episode, Haylie Pomroy speaks with Dr. Angela Taylor, Doctor of Clinical Nutrition, to discuss how laboratory testing is conducted and applied within a personalized medicine framework.

They explore why obtaining a micronutrient panel that evaluates intracellular levels is essential, what components should be included in a comprehensive thyroid panel, and which markers warrant careful evaluation when a patient presents with elevated antibodies.

Dr. Taylor also recommends laboratory options for patient testing, explains how free, reverse, and synthetic T3 and T4 influence physiological function, and discusses how iron, ferritin, and vitamin D interact to support overall health and metabolic balance.

Learn from the experts themselves here on Fast Metabolism Matters - Functional Lab Markers That Actually Matter.

Dr. Angela Taylor is a Doctor of Clinical Nutrition based in Baltimore, MD. She's double board-certified in both clinical nutrition and functional medicine with a private practice (BrainFood Nutrition) and also serves as Adjunct Faculty at Johns Hopkins University and Nova Southeastern University, teaching Clinical Nutrition. Her specialty areas include Gluten-Free, Autism, ADHD, Sports Nutrition, and Herbal Medicine.

Website: https://www.angelataylor.com/

Facebook: https://www.facebook.com/AngelaTaylor8/

LinkedIn: https://www.linkedin.com/in/dr-angela-taylor-dcn-cns-ldn-ifmcp-0776b122/

YouTube (The Singing NutriDoc): https://www.youtube.com/@SingingNutriDoc

YouTube (Brainfood Nutrition Autism ADHD): https://www.youtube.com/@BrainfoodNutrition

Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.

Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com

Instagram: https://www.instagram.com/hayliepomroy

Facebook: https://www.facebook.com/hayliepomroy

YouTube: https://www.youtube.com/@hayliepomroy/videos

LinkedIn: https://www.linkedin.com/in/hayliepomroy/

X: https://x.com/hayliepomroy

In today's episode of Fast Metabolism Matters, Dr. Marc Kesselman joins us for an in-depth discussion on autoimmunity, including its definition, physiological impact on the body, and current developments in treatment and management.

We explore why autoimmune conditions disproportionately affect women, the role of autoimmunity in post-infectious illnesses, its genetic components, and the importance of proper nutrition and awareness in the healing process. Dr. Kesselman also shares clinical insight on the relationship between alcohol, exercise, and autoimmune flares, along with expert guidance on strategies to help prevent autoimmune disease progression.

Know how nutrition plays a role in managing autoimmune diseases here on the Fast Metabolism Matters podcast!

Dr. Marc Kesselman is the chair and associate professor at the Department of Internal Medicine at Dr. Kiran C. Patel College of Osteopathic Medicine. He is also the chief of the Division of Rheumatology at Nova Southeastern University. Dr. Kesselman received his medical degree from Des Moines University College of Osteopathic Medicine and has been in practice for more than 20 years.

LinkedIn: https://www.linkedin.com/in/marc-m-kesselman-d-o-facoi-facc-facr-6491479/

Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.

Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com

Instagram: https://www.instagram.com/hayliepomroy

Facebook: https://www.facebook.com/hayliepomroy

YouTube: https://www.youtube.com/@hayliepomroy/videos

LinkedIn: https://www.linkedin.com/in/hayliepomroy/

X: https://x.com/hayliepomroy