Comedian and former paramedic James Frey (@jamesfreycomedy) joins Andy, Jesse and Matt to talk about firefighter dreams and emergency medicine reality, James' Ventura comedy show, giving CPR in civilian life, a woman (well, women) who couldn't burp, getting fobbed off, sucker fish hiding in manta rays' butts, a quantum battery breakthrough and missing scientist conspiracy theories.

Comedian Shane Mauss (@shane_mauss) returns to the show to talk about his upcoming comedy special TRIPS: The First Dose, how LSD affects blind people, misophonia's link to anxiety and depression, the goring of a matador's ass, plants 'hearing' rain coming and Shane's comedy/science podcast Here We Are.

Comedian Brandie Posey (@brandazzle) returns to the show to talk with Jesse, Andy and Matt about the geography of Jersey, Brandie's label Burn This Records and her new comedy special Milk Job, Andy's other ska band, why humans can't regenerate limbs, a huge volcano refilling with magma, the dude who got both his arms reattached in 1992, whether Yellowstone is due for an eruption and Fruit Love Island.

Comedian/speechwriter Chandler Dean (@chandlerjdean) joins Jesse, Andy and Matt to talk about his show Abolish Everything!, Jesse's over-the-top stuffed animal purchase, poop speed as a health indicator, the Bristol Stool Chart, medical fake poo, Jesse's obsessions with fake foods, giant stuff and really tiny stuff, Artemis II's avatar crewmates, the magic of Tiny Empath Babies, videos of Tiny Empath Babies and more videos of Tiny Empath Babies.

Comedian Amber Preston (@prestonparty) returns to help Andy, Jesse and Matt celebrate the big six-oh-one and talk about Artemis II, frozen urine in space, a microbe that makes you stronger, Trump's insane handshakes, sharks testing positive for cocaine and sperm difficulties in zero-g.

Comedian Katie Novotny (@katienovotnyyyyy) joins Matt and Andy to discuss her special Son of Your Dreams, whale junk, headbutting whales, the 20-year cycle of fashion, an evolved arsenic tolerance, Thai children who can see underwater and a Warsaw Poland Bros. song Andy plays on.

Comedian Monica Nevi (@monicanevi) joins Andy, Jesse and Matt to talk about her special Big Stepdad Energy, what VO2 max means, esports scholarships, vasectomy rate spikes during March Madness, the effect of carbonated water on gamer performance, a bunch of human brain cells in a petri dish playing Doom, unlocking the antibacterial secrets of frogs and using frogs to keep milk from spoiling.

Comedian Matthew Coe (@matthew_coe__) joins Jesse, Andy and Matt to talk about parents watching comedy, Matthew's show My Therapist Knows Your Name, Matthew's hypoplastic right heart syndrome, the closing of the foramen ovale, a Japanese study of falling cats, a robot handling potato chips, and an averted Moon asteroid close call.