Retinal Pigment Epithelium Physiology
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Retinal Pigment Epithelium Physiology
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Episode 45 – Retinal Pigment Epithelium Physiology
Welcome back to Basic Sciences in Ophthalmology.
Hi, I am Dr Thomas Whitelaw and in this episode, we explore one of the most important yet often underappreciated tissues in the eye: the retinal pigment epithelium, or RPE.
Although only a single layer of cells, the RPE performs a remarkable range of functions essential for retinal health and visual function. It forms part of the outer blood-retinal barrier, supports photoreceptor metabolism, participates in the visual cycle, removes cellular waste, and helps maintain the delicate physiological environment required for vision.
Many important retinal diseases, including age-related macular degeneration, involve dysfunction of the retinal pigment epithelium.
Today we will discuss:
1. RPE structure and function
2. Phagocytosis of photoreceptor outer segments
3. The role of the RPE in disease, particularly age-related macular degeneration