This release contains only the music track from Base by Base Episode 404.

Song title: Scars That Tell the Truth
Original Base by Base episode: 404: HRD-GIS refines BRCA1/2 variant classification in ovarian cancer

Article metadata:
Article title: Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2026.05.015
Reference: Schnaiter S., Santer F.R., Csanaky K.A., et al. Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity. The American Journal of Human Genetics. 113, 1–8 (2026). https://doi.org/10.1016/j.ajhg.2026.05.015

Lyrics:
Verse 1
On bright screens in the midnight lab,
we chase a pattern we can’t quite grab.
Shattered ladders, missing rungs,
a quiet code on silver tongues.
In the wreckage, numbers glow.

Pre-Chorus
If repair goes dark, the story shows,
in loss of pieces, how it grows.
A fingerprint you can’t erase,
drawn in the genome’s broken place.
Let the signal cut through doubt.

Chorus
These scars don’t lie, they light the way,
turn the maybe into “name it” today.
When the fix is gone, the fracture’s loud,
HRD speaking through the crowd.
Hold the line—let evidence stay:
scars that tell the truth today.

Verse 2
Four cohorts singing, one refrain,
thousands of tumors in the chain.
When GIS rises past the line,
BRCA shadows intertwine.
When it’s low, the fear steps back.

Bridge
Not every variant wears a crown,
some live in grey, some won’t come down.
So we weigh the odds, we map the chance,
likelihood turning into stance.
A measured spark in clinic halls—
a clearer call when darkness falls.

Final Chorus
These scars don’t lie, they light the way,
turn the maybe into “name it” today.
High score, strong pull—support the claim,
low score can quiet a warning name.
From broken repair, a brighter view:
scars that tell the truth—break through.