In this episode of the Long COVID Clinical Podcast, hosted by Drs. Tiffany Walker, Anita Chopra, and Aaron Friedberg, the team welcomes Dr. Abby Cheng, an expert in physical medicine and rehabilitation. Dr. Cheng discusses the development and impact of the AAPMR's comprehensive guidance on long COVID, emphasizing the importance of multidisciplinary approaches to treatment. The conversation covers the evolution of symptom-specific guidelines into a practical compendium for primary care providers, highlighting the need for real-time support in managing long COVID. Dr. Cheng also addresses the challenges of pharmacological management, the significance of recognizing long COVID in differential diagnoses, and the latest updates on potential treatments and ongoing research efforts. The episode concludes with insights into the NIH's RECOVER TLC trials, offering hope for future advancements in long COVID care.

Edited and Produced by Christopher Chiu and Carissa Lee

This episode of the Long COVID Clinical Podcast, hosted by Drs. Anita Chopra, Andrew Schamess, and Aaron Friedberg, features Dr. Hector Bonilla, an infectious disease specialist from Stanford University School of Medicine. The discussion centers on the innovative use of repurposed medications like low-dose naltrexone and Abilify in treating long COVID and ME/CFS. Dr. Bonilla shares insights into the overlap between these conditions, highlighting symptoms such as fatigue and brain fog, and explores how these symptoms can be managed with off-label therapies. He explains the science behind targeting immune pathways and the potential of these drugs to reduce inflammation and improve patient outcomes. The episode also covers Dr. Bonilla’s clinical trials, dosing protocols, and the promising results seen in patients. It concludes with practical strategies for clinicians and patients, emphasizing the importance of evidence-based approaches in managing chronic illness.

Edited and Produced by Christopher Chiu and Carissa Lee

This episode of the Pediatric Long COVID Podcast, hosted by Drs. Anita Chopra and Andrew Schamess, features Dr. Laura Malone, Director of the Pediatric Post-COVID-19 Rehabilitation Clinic at the Kennedy Krieger Institute. The discussion centers on the unique manifestations of long COVID in children, highlighting differences in symptoms compared to adults, such as neurological and gastrointestinal issues. Dr. Malone elaborates on the diagnostic challenges faced when children lack confirmed prior COVID infection and emphasizes the importance of a multidisciplinary approach involving neurologists, rehabilitation specialists, and mental health professionals. She also explores the current prognosis for pediatric patients, the role of emerging research in understanding physiological differences, and the success of the Pediatric Long COVID ECHO telementoring program. The episode concludes with insights into reducing stigma around post-viral syndromes in children and the ongoing need for research and education in this evolving field.

Edited and Produced by Christopher Chiu and Carissa Lee

This episode of the Long COVID Clinical Podcast, hosted by Drs. Anita Chopra and Andrew Schamess, delves into the phases of COVID-19 infection, underlying mechanisms, diagnostic biomarkers, and novel therapeutics with Dr. Daniel Griffin, a renowned infectious disease specialist and host of the "This Week in Virology " podcast. The discussion covers the progression and diagnosis of long COVID, pathobiology theories, and the involvement of the autonomic nervous system and small fiber neuropathy. Dr. Griffin highlights practical biomarkers for clinical use and discusses both non-pharmacological and pharmacological treatment strategies. The conversation also addresses the impact of funding changes on research progress and future directions for managing long COVID. The episode concludes with a hopeful outlook on collaborative efforts to advance understanding and improve patient care in the face of long COVID challenges.

Edited and Produced by Christopher Chiu and Carissa Lee

In this episode of the Long COVID Clinical Podcast, hosted by Drs. Anita Chopra, Andrew Schamess, and Tiffany Walker, physician-scientist Dr. Linda Geng discusses the complexities of diagnosing and treating long COVID, the overlap with other infection-associated chronic conditions, and ongoing research efforts. Her clinical and research expertise sheds light on the heterogeneity of long COVID and potential therapeutic avenues, including the clinical approach to diagnosing long COVID and the current lack of biomarkers, phenotypic clusters and heterogeneity of long COVID patients, research directions such as repurposing drugs, pathobiology, and large-scale studies, strategies for rehabilitation and management of post-exertional malaise, and the importance of collective research efforts and future directions in long COVID care.

Edited and Produced by Christopher Chiu and Carissa Lee

This episode of the Long COVID Clinical Podcast, hosted by Drs. Anita Chopra, Andrew Schamess, and Aaron Friedberg, features Dr. Nikhil Kamat in a discussion of hematological complications in long COVID. Dr. Kamat, a clinical assistant professor at the University of Washington School of Medicine, shares his expertise on microclots and immune dysregulation, revealing why current diagnostics often miss microvascular damage. The discussion delves into the formation of microclots, their manifestation in organs, and the limitations of traditional tests like D-dimer. Dr. Kamat highlights the role of inflammation in endothelial damage and discusses who is most at risk for blood-related complications post-COVID. The episode also covers emerging treatment considerations, including the controversial idea of prolonged anticoagulation, and emphasizes the importance of balancing treatment risks. This insightful conversation offers critical knowledge for clinicians, researchers, and anyone interested in the long-term impacts of COVID, providing a pathway to more targeted therapies and better patient outcomes.

Edited and Produced by Christopher Chiu and Carissa Lee

In this episode of the Long COVID Clinical Podcast, hosts Andrew Schamess and Anita Chopra discuss recent research on Long COVID at Ohio State University. They are joined by Dr. Amal Amer, a Professor of Microbial Infection and Immunity, and Dr. Heba Amer, who works in Dr. Amal's lab. Dr. Amal shares her personal experience with Long COVID and details her research on the inflammasome and caspase-4/11, proteins linked to severe inflammation and cognitive issues in Long COVID. The discussion highlights the relationship between these proteins and the inflammatory response, potential coagulopathy, and how this research could lead to new treatments. Dr. Heba Amer describes using an advanced behavioral testing system for mice to study cognitive dysfunctions related to Long COVID. The findings offer promising avenues for drug discovery and a deeper understanding of Long COVID's pathology. Additionally, future research plans and the importance of correlating mouse model data with human samples are discussed. The episode concludes with optimism about ongoing and future research efforts.

Edited and Produced by Christopher Chiu

This episode of the Long COVID Clinical Podcast, hosted by Drs. Anita Chopra, Tiffany Walker, Andrew Schamess, and Aaron Friedberg, features Dr. Andrew Ayers, a specialist in allergy and immunology. The discussion focuses on the immunological processes involved in long COVID, including immune dysregulation, immune deficiency, and the role of mast cell activation syndrome (MCAS). Dr. Ayers explains the complexities of the immune system's response to long COVID, potential treatments like high-dose antihistamines and other therapies, and the impact of COVID and vaccinations on immune reactions. He also delves into patient phenotypes, drug allergies, and the gut microbiome's influence on immune responses. The episode concludes with a comprehensive review of MCAS management strategies and emphasizes the challenges faced by clinicians treating long COVID.

Edited and Produced by Christopher Chiu