Welcome back to The Popkin Method, where we connect symptoms to science, and science to solutions. In today’s episode, we're tackling one of the biggest blind spots in modern medicine: perimenopause and menopause. Millions of women are told their labs are normal while silently struggling with fatigue, anxiety, weight gain, sleep disruption, and a loss of vitality. But what if these symptoms aren’t random? What if they’re actually signals from your body?

Dr. Matthew C. Popkin breaks down the complex physiologic transition of midlife hormonal change and reveals how the Popkin Method offers a systems-based, whole-body approach. We’ll dive into lifestyle medicine, nutrition, exercise, strategic supplementation, hormone modulation, peptides, regenerative medicine, and the science of longevity. If you’ve ever felt dismissed or misunderstood during this phase of life, or you want a better strategy than band-aid solutions and social media fads, this episode is for you. Let’s get started and redefine what thriving through menopause can look like.

Timestamps:

00:00 Understanding menopause and the Popkin method

06:07 Weight gain frustrations and body changes

06:57 Menopause and weight gain issues

12:28 Diet tips for maintaining muscle

16:06 Choosing quality supplements

19:15 Importance of individualized hormone therapy

22:00 Importance of Testosterone in Women

26:44 Testosterone therapy options for women

27:47 Testosterone treatment methods and issues

31:29 Benefits of Testosterone Therapy

33:57 Testosterone and breast cancer risk

37:47 Testosterone therapy side effects

42:33 Discussing peptide treatments and benefits

44:47 Discussing GLP-1 medications usage

48:01 Discussing regenerative medicine basics

52:07 Discussing effective menopause treatments

54:22 Discussing women's health and longevity

You can see Dr. Popkin through his online virtual functional medicine program anywhere in the country or the world for that matter.

You can visit Dr. Popkin in his Hollywood Florida office for an in person weight loss experience.

Visit thepopkinmethod.com to send a message to schedule an appointment with Dr. Popkin or email Dr. Popkin at mcpopkinmd@yahoo.com.

Podcast Website - https://thepopkinmethod.com/

Matthew C. Popkin, M.D. - https://thepopkinmethod.com/about

Podcast Partner - TopHealth - https://tophealth.care/

“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Welcome to The Popkin Method, where we cut through the noise of miracle weight loss solutions and trendy shortcuts dominating social media and advertising today. In this episode, Dr. Matthew C. Popkin takes a deep, clinical dive into GLP-1-based therapies like semaglutide and tirzepatide, some of the most talked-about tools in modern medicine. But here’s the catch: these medications aren’t magic fixes. Instead, Dr. Matthew C. Popkin unpacks the importance of a comprehensive, sequenced approach that prioritizes lifestyle optimization, strategic nutrition, resistance-based training, and targeted supplementation before even considering medication.

We’ll explore why so many struggle to keep weight off after stopping these peptides, why even lean individuals can battle insulin resistance, and how stacking the right peptides with solid foundational habits creates sustainable results. This isn’t about chasing the next health trend, it’s about reclaiming control of your physiology and building a system that actually works for the long-term. Let’s get into it.

Timestamps:

00:00 Success with GLP1 weight loss peptides

03:58 Critiquing wellness influencer marketing

10:22 Navigating modern marketing challenges

11:57 Supervised weight loss and lifestyle changes

14:42 Understanding Skinny Fat and Metabolic Health

19:29 Prioritize fiber and healthy fats

21:46 Spacing Protein Intake

26:23 Maintaining Muscle with Diet and Exercise

28:22 GLP1 therapies and liver health

32:50 Prepping your body for medication

34:20 GLP1 Medication Reset Protocol

37:31 Peptide stacking with physician guidance

40:54 Choosing the right peptides

46:51 Addressing Insulin Resistance Strategies

50:47 Avoiding medication dependency

53:22 Understanding the Popkin Method

55:04 Introduction to the Popkin Method

You can see Dr. Popkin through his online virtual functional medicine program anywhere in the country or the world for that matter.

You can visit Dr. Popkin in his Hollywood Florida office for an in person weight loss experience.

Visit thepopkinmethod.com to send a message to schedule an appointment with Dr. Popkin or email Dr. Popkin at mcpopkinmd@yahoo.com.

Podcast Website - https://thepopkinmethod.com/

Matthew C. Popkin, M.D. - https://thepopkinmethod.com/about

Podcast Partner - TopHealth - https://tophealth.care/

“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Welcome back to The Popkin Method! In today’s episode, Dr. Matthew C. Popkin tackles one of the most misunderstood, yet critical, obstacles to lasting weight loss and wellness: fatty liver disease. Most people think of it as just a byproduct of poor diet or being overweight, but as you’ll learn today, fatty liver is actually a hidden metabolic bottleneck that could be sabotaging your best efforts to get healthy.

If you’ve ever felt inexplicably stuck with your weight, tired for no clear reason, frustrated by slow progress even with medications, or overwhelmed by conflicting health advice online, this episode is for you. Dr. Matthew C. Popkin will break down what fatty liver disease really is, why it develops silently, and most importantly, how his signature four-phase Popkin Method can help you reverse it with a sustainable, physician-guided approach that goes far beyond gimmicks, fad diets, or quick fixes.

We’ll cover the common symptoms, the pitfalls of “magic bullet” solutions, and exactly which steps you need to take, from food choices and sleep, to advanced therapies, to restore your liver health, unlock your metabolism, and finally achieve lasting change. Whether you’re new to The Popkin Method or following along since episode one, you’ll walk away with a clear, actionable blueprint to take control of your health.

Ready to cut through the noise? Let’s dive into the truth about fatty liver disease and discover how to get truly unstuck.

Timestamps:

00:00 Understanding fatty liver disease

09:57 Understanding fatty liver and GLP1 meds

14:04 Supporting fat utilization strategies

19:21 Understanding fasting and diet choices

25:06 Common intermittent fasting mistakes

30:07 Replacing carbs with veggies and fats

36:32 Anti-inflammatory foods and coffee benefits

37:44 Choosing the right protein shake

47:04 Trustworthy supplements for fatty liver

50:05 Discussing stem cell therapies

59:29 Hormone modulation with supplements

01:03:48 Steps for improving liver health

01:09:32 Understanding the Popkin Method

01:11:14 Sharing The Popkin Method

You can see Dr. Popkin through his online virtual functional medicine program anywhere in the country or the world for that matter.

You can visit Dr. Popkin in his Hollywood Florida office for an in person weight loss experience.

Visit thepopkinmethod.com to send a message to schedule an appointment with Dr. Popkin or email Dr. Popkin at mcpopkinmd@yahoo.com.

Podcast Website - https://thepopkinmethod.com/

Matthew C. Popkin, M.D. - https://thepopkinmethod.com/about

Podcast Partner - TopHealth - https://tophealth.care/

“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”