Glen McGugan, Ph.D., Director of ASM's Mechanism Discovery Unit, discusses how curiosity‑driven research—from parasite virulence to CRISPR and complex microbial systems—drives tomorrow's breakthroughs.

• Mechanism discovery,encompasses all of the foundational basic research across the microbial sciences and is essential for all advances in microbial science.
• Many transformative technologies (e.g., CRISPR) originated from curiosity-driven, basic research rather than immediate practical goals.
• McGugan's experience as a Program Officer at NIH provided him with a broad perspective on the research pipeline, from basic science to clinical trials, and highlighted the importance of supporting early-career scientists.
• Developing therapeutics for parasitic diseases is particularly challenging due to complex life cycles and limited financial incentives for pharmaceutical companies; much of the progress relies on government and philanthropic funding.
• ASM's Mechanism Discovery Unit serves as a neutral hub to convene interdisciplinary stakeholders, foster collaboration, and advance fundamental research.
• Safeguarding future breakthroughs in the microbial sciences depends on the involvement of and connections between researchers, policymakers, funders and industry partners to close gaps between discovery, implementation and impact.