Lipoprotein (a) (Lp(a)) was discovered in 1963 by a Norwegian geneticist by the name of Kåre Berg who studied particles that carried cholesterol in the blood. He found some patients had an additional protein on the low-density lipoprotein. Studies found that patients with elevated Lp(a) had increased risks of cardiovascular disease. However, the levels were not affected by diet, environmental factors, or medications. The result is that this test was largely ignored for the last few decades.

Recent dyslipidaemia guidelines released by the United States and Europe have returned a focus back on to Lp(a). They recommend that patients should have Lp(a) tested once throughout their life to assess their cardiovascular disease risk. The result can help identify which patients are at a higher risk of cardiovascular morbidity and mortality and who will benefit from lifestyle modification and early intervention.

This resource is referenced during the discussion: https://www.lpaclinicalguidance.com/

This is the story of lipoprotein (a).

Our Special Guests:

Dr Michael Page is a chemical pathologist at Clinipath in Perth, senior lecturer at the UWA Medical School, and immediate past President of the AMA (WA).

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Skin has always told stories. For thousands of years, those whose skin behaved differently — scaling, thickening, inflaming — were feared, isolated, and misunderstood. Psoriasis was long lumped together with leprosy, its sufferers cast out rather than cared for.

It would take centuries before medicine began to separate these conditions, and longer still before we understood what was really happening beneath the surface. Psoriasis is not an infection, not a curse, not a failure of hygiene. It is the immune system turning on itself, a complex, chronic inflammatory disease that affects not just skin but joints, confidence, and quality of life. It touches roughly 2-3% of the population, and for many it is a lifelong companion.

Today we have a clinical dermatologist and a dermatopathologist to help us understand what psoriasis looks like to the clinician, what it reveals under the microscope, and how our understanding of its immunological roots has transformed the way we treat it.

This is the story of psoriasis.

Our Special Guests:

Associate Professor Laura Scardamaglia, a Consultant Dermatologist, a Fellow of the Australasian College of Dermatology, and Clinical Associate Professor at the University of Melbourne.

Dr Grace Liu is an Anatomical Pathologist with Histopath in Sydney, Australia.

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The Artful Dodger is a television series on Disney+ that is a historical medical drama set in 1850s Australia with Jack Dawkins, the Artful Dodger from the world of Oliver Twist. Jack is a former pick pocket now surgeon who is reacquainted with old partner in crime, Fagin, who is keen for Jack to resume old habits.

The Artful Dodger takes pride in being one of the most historically accurate depictions of nineteenth century medicine and surgery. The hospital, surgical tools, and treatments are accurate portrayals of what we knew back then. We organised a discussion with its creator to take a deep dive into this entertaining show that both myself and Steve thoroughly enjoyed.

This is the story of The Artful Dodger

Our Special Guest:

James McNamara who is the creator, showrunner, head writer, and executive producer of The Artful Dodger available on Disney+.

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This Medical Life podcast is available on all podcasting services and Spotify. Help support us on our donation page.

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