『Your Brain On』のカバーアート

Your Brain On

Your Brain On

著者： Drs. Ayesha and Dean Sherzai
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A podcast about the neuroscience of everything. From neurologists, researchers, and public health advocates Drs. Ayesha and Dean Sherzai, explore every aspect of our world through a neuroscientific lens, with science-based stories, interviews, anecdotes, and brain health facts. Equip yourself with neurologically sound answers to life's everyday health questions and learn the essentials of brain health and optimization, one topic at a time.2024 科学 衛生・健康的な生活
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  • Your Brain On... Insomnia

    Your Brain On... Insomnia
    2026/06/03

    It's 3 AM and your brain won't shut off. About 1 in 10 adults meets the clinical definition of chronic insomnia, and most never get treated. Instead, they scroll through an endless aisle of magnesium gummies, melatonin, and $300 trackers that don't address the real problem.

    We brought in a neurologist and a psychologist who never spoke to each other and landed on almost the exact same conclusions.

    In this episode, you'll learn:

    • How the brain's glymphatic cleaning system works during sleep and why chronic insomnia is a brain health problem
    • Why melatonin is a darkness signal, not a sleeping pill, and how nocturnal animals prove the point
    • A sleep neurologist's honest 1-to-10 ratings of every sleep aid you've heard of: magnesium (2/10), CBT-I (10/10), alcohol (-10/10), and 12 more
    • What orthosomnia is and why your sleep tracker might be making your insomnia worse
    • Why perimenopause and menopause create what one expert calls "a perfect storm" for sleep disruption, and why doctors keep missing sleep apnea in women
    • How CBT-I works: sleep restriction, stimulus control, and why your therapist will tell you to spend less time in bed, not more
    • The data showing CBT-I may outperform hormone therapy for menopausal insomnia
    • ACT therapy for insomnia: a different approach for people who get more anxious from CBT-I
    • Blue light, naps, the 8-hour rule, catching up on weekends: what holds up and what doesn't
    • Five steps to start tonight, and why you should pick just two

    Dr. Sujay Kansagra is a pediatric neurologist and sleep medicine specialist at Duke University, director of Duke's Pediatric Neurology Sleep Medicine Program, and author of "My Child Won't Sleep."
    Follow Dr. Kansagra: @thatsleepdoc

    Dr. Shelby Harris is a clinical psychologist and behavioral sleep medicine specialist. She treats insomnia in women during perimenopause and menopause and is the author of "The Women's Guide to Overcoming Insomnia."
    Website: drshelbyharris.com
    Follow Dr. Harris: @SleepDocShelby

    Hosted by Drs. Ayesha & Dean Sherzai
    Subscribe to The Synapse (free weekly newsletter): thebraindocs.com/newsletter
    Follow @TheBrainDocs on Instagram
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    1 時間 38 分
  • Your Brain On... Microplastics

    Your Brain On... Microplastics
    2026/05/27

    Headlines warned us about microplastics in our brains. A chemist says the study may have been measuring brain fat instead.

    In 2025, a study claiming microplastics accumulate in human brain tissue dominated our feeds. We covered it. Then Dr. Michelle Wong, a chemical scientist and science communicator, flagged a problem with the methodology.

    So we went to the primary literature, read the critique, and brought in one of the first scientists to publicly challenge the findings: Dr. Oliver Jones, Professor of Analytical Chemistry at RMIT University in Melbourne.

    In this episode, we unpack what went wrong with the measurement method, what it means for the broader microplastics conversation, and why being willing to say "I was wrong" is so vital for good science.

    In this episode:

    • How pyrolysis GC-MS works and why it can confuse plastic breakdown products with brain fat
    • Why potassium hydroxide digestion creates soap, which also mimics plastic signatures
    • The contamination problem: body bags, centrifuge tubes, plastic storage containers, and lab air
    • Why 7 grams of microplastic per brain is more than what researchers find in raw sewage
    • The Marfella study in The New England Journal of Medicine: microplastics in arterial plaques and why it also lacked blank controls
    • How microplastics could enter the body: skin absorption, ingestion, and inhalation
    • Why PM2.5 monitoring already captures the most relevant airborne microplastic exposure
    • What the WHO, FDA, and European Food Safety Authority have concluded about microplastic harm
    • What better microplastics research would actually look like
    • Why the real lesson is about how we evaluate headlines, not just microplastics

    Dr. Oliver Jones is Professor of Analytical Chemistry and Associate Dean of Biosciences and Food Technology at RMIT University in Melbourne. A Fellow of the Royal Society of Chemistry (FRSC) and the Royal Australian Chemical Institute (FRACI), he holds degrees from Imperial College London and Cambridge. He is one of only 118 scientists worldwide named to the IUPAC Periodic Table of Outstanding Younger Chemists. His research focuses on developing methods to measure environmental contaminants, including microplastics, and he was among the first scientists to publicly challenge the methodology of the viral "microplastics in the brain" study.

    Follow Dr. Jones: @dr_oli_jones
    RMIT faculty page: rmit.edu.au/oliver-jones

    Dr. Michelle Wong (Lab Muffin Beauty Science) first flagged the methodological concerns to us.

    Hosted by Drs. Ayesha & Dean Sherzai
    Subscribe to The Synapse (free weekly newsletter): https://thebraindocs.com/newsletter
    Follow @TheBrainDocs on Instagram
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    31 分
  • Your Brain On... Menopause Hormone Therapy

    Your Brain On... Menopause Hormone Therapy
    2026/05/13
    Menopause hormone therapy and your brain: what the evidence says vs. what the algorithm is selling you. Two-thirds of Alzheimer's patients are women. That statistic has fueled a social media narrative that hormone therapy can prevent dementia, but the current evidence doesn't support that claim. In this episode, Drs. Ayesha and Dean Sherzai sit down with OBGYN Dr. Jen Gunter and neuroscientist Dr. Sarah McKay to separate the science from the soundbites. Your Brain On... Menopause Hormone Therapy [Season 7, Episode 1] Get our FREE NEURO Plan Brain Health Playbook: https://thebraindocs.com/playbook In this episode: Why menopause hormone therapy is the gold standard for hot flashes and night sweats but not a proven tool for dementia preventionThe Women's Health Initiative: what it actually found, how the press conference distorted the findings, and what we've learned sinceWhy "bioidentical hormones" is a marketing term, not a medical one, and what that means for the products being sold to youHow the hypothalamus drives vasomotor symptoms and why sleep disruption may explain much of the cognitive fog women experience at midlifeThe high placebo response rate with hormone therapy and why dose escalation can mask a missed diagnosisWhy the simplistic narrative of "women get more Alzheimer's, so it must be menopause, so give hormones" falls apart under scrutinyHow over-testing, unregulated lab panels, and wearable hormone data can create more anxiety than answersThe case for perimenopause as a life stage, not a disease, and why medicalizing normal midlife stress upholds harmful structuresWhat the aging brain actually gains: vocabulary, emotional processing, wisdom, complex problem-solving, and the capacity to hold nuance7 evidence-based actions you can take this week for your brain health, no prescription requiredWhy the FDA's removal of the black box warning on hormone therapy was released without context and what happened next on social mediaThe new neurokinin receptor antagonists and why they could change how we study the relationship between hot flashes and brain health 00:00 Intro 01:09 Why the menopause hormone therapy conversation matters 07:10 Dr. Jen Gunter: the dangerous dichotomy around MHT 10:20 The Women's Health Initiative, revisited 16:25 Who is menopause hormone therapy actually for? 18:20 The placebo response nobody talks about 22:33 When does perimenopause actually start? 26:00 Does MHT actually prevent dementia? 29:11 "Bioidentical" is not a medical term 36:27 The problem with unregulated hormone testing 41:08 How to advocate for yourself at the doctor 44:36 New drugs that could change menopause research 47:17 The pTau217 study and what it means for women on MHT 52:20 Dr. Sarah McKay: what happens in your brain during menopause 59:34 The oversimplified estrogen-Alzheimer's story 1:04:13 When social media primes your symptoms 1:11:18 What the aging brain actually gains 1:21:35 Grandmothers rule the world! 1:25:43 What MHT is actually good for 1:26:28 7 things to do for your brain Dr. Jen Gunter is an OBGYN, pain medicine physician, New York Times columnist, and bestselling author of The Menopause Manifesto, The Vagina Bible, and Blood. She writes The Vajenda on Substack and is one of the most prominent voices challenging misinformation in women's health. Dr. Sarah McKay is a neuroscientist, science communicator, and author of The Women's Brain Book. She is the founder of The Neuroscience Academy and Think Brain training programs. References: North American Menopause Society 2022 Hormone Therapy Guidelines: menopause.org Australasian Menopause Society: menopause.org.au The Vajenda (Substack): jenssubstack.com Get our FREE NEURO Plan Brain Health Playbook: https://thebraindocs.com/playbook Hosted by Drs. Ayesha & Dean Sherzai. Subscribe to The Synapse (free weekly newsletter): thebraindocs.com/newsletter Follow @TheBrainDocs on Instagram
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    1 時間 29 分
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