『Knife Down』のカバーアート

Knife Down

Knife Down

著者： Lily Johnston MD MPH
無料で聴く

"Knife Down" is what a surgeon says in the OR when she puts her scalpel down so no one gets hurt — and it’s the mission here: put the knife down, long before anyone needs to use it.


Knife Down is a podcast about how to actually invest in your health so you can live longer, stronger, and with less time in doctors’ offices. The core focus is the world’s leading cause of death—cardiovascular disease—and what to do about it before it shows up as a catastrophe.


Hosted by a vascular surgeon on a mission to put herself out of business, the show translates cutting-edge science on prevention, metabolic health, and longevity into real-world strategies you can use in clinic or at your kitchen table. Expect evidence, nuance, and zero wellness hype—plus the occasional dark joke about the state of modern medicine.

© 2026 Knife Down 衛生・健康的な生活 身体的病い・疾患
エピソード
  • Try THIS instead of Nattokinase (Surgeon Explains)

    Try THIS instead of Nattokinase (Surgeon Explains)
    2026/06/30

    The nattokinase video clearly hit a nerve. Your comments were sharp, occasionally feisty, and worth a real answer. So this is the follow-up Q&A: natto the food versus nattokinase the isolated capsule, whether CIMT is a test I actually trust, the dosing argument a lot of you raised, and the supplement many of you asked about instead — lumbrokinase.

    The back half is a proper walk through the one randomized trial testing lumbrokinase for secondary stroke prevention. I go through the design, the parts that gave me pause, and the plaque and IMT findings that genuinely caught my attention. My take, for what it's worth with the evidence we have: if you're going to hang your hat on an enzyme, lumbrokinase looks like the safer bet. Watch and decide for yourself.

    ⏱️ CHAPTERS
    0:00 Why I'm answering your nattokinase comments
    0:25 Natto the food vs. nattokinase the supplement
    1:54 Is nattokinase the same as vitamin K2?
    2:46 Do I trust CIMT? Plaque vs. IMT, explained
    3:59 The "n=1" critique, Susan, and Dr. Brewer
    6:01 The dosing fight: 2,000 vs. 10,800 FU
    7:58 Lumbrokinase and serrapeptase: what they actually are
    10:22 The 2013 lumbrokinase stroke trial: setup
    13:09 Where the trial design gives me pause
    15:46 Results: the patients and the open-label problem
    17:26 Baseline data and the missing standard meds
    20:20 Lab results: fibrinogen, CRP, D-dimer, tPA
    22:29 The interesting part: plaque and IMT changes
    24:57 Stroke scores, outcomes, and the low event count
    27:52 How lumbrokinase differs from nattokinase (and why it's likely safer)
    30:15 Bottom line: should you take it?

    📚 STUDY DISCUSSED
    Cao YJ, Zhang X, Wang WH, et al. Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention: results from a multicenter, randomized, parallel-group and controlled clinical trial. Chin Med J (Engl). 2013;126(21):4060-4065. PMID: 24229674. https://pubmed.ncbi.nlm.nih.gov/24229674/

    ▶️ WATCH NEXT
    "I Stopped Using Nattokinase. Here's Why.": https://youtu.be/vpenJQ3UJh0
    The VitaK-CAC study: https://youtu.be/ArxAXtzsue4
    Vit K Comments & Questions: https://youtu.be/uORGxMsedic

    ⚕️ DISCLAIMER
    This channel is for education, not medical advice. I'm a board-certified vascular surgeon, but I'm not your surgeon, and nothing here replaces a conversation with your own physician. Supplements carry real risks, including bleeding. Talk to your doctor before starting, stopping, or changing anything — especially if you take blood thinners or antiplatelet medication.

    💬 Found this useful? Subscribe, and drop your lumbrokinase questions in the comments. We'll get to as many as we can next time.

    Sign up for more information on my own practice here: https://corsighthealth.com/

    High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start

    Other tools for optimal health (note these are affiliate links):
    Home BP Cuff: https://amzn.to/49Cq7rh
    Sonicare Toothbrush: https://amzn.to/3KllfMS
    WaterPik: https://amzn.to/4894Xi8
    Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d
    Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS
    Intake Breathing Nasal Support: https://amzn.to/48dfQQ1
    Personal Blender: https://amzn.to/4pyNGGl
    True Nutrition Protein: https://oken.do/q2xzqeqw
    Glass Meal Prep Containers: https://amzn.to/4ocEPJ2
    Sleep Mask: https://amzn.to/48fSJV5
    Air Purifier: https://amzn.to/4puzTQZ

    ___________________________
    🧬 About Dr. Lily Johnston

    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota
    続きを読む 一部表示
    31 分
  • I Stopped Using Nattokinase. Here’s Why.

    I Stopped Using Nattokinase. Here’s Why.
    2026/06/24

    Nattokinase is one of the most hyped supplements in cardiovascular health — claimed to lower blood pressure, shrink arterial plaque by 36%, and drop LDL cholesterol without a statin. I put a patient on it. Then I looked closer at the data. Now I've stopped.

    In this video, I break down what the evidence actually shows:

    ✅ Blood pressure: Real, but modest. A 2023 meta-analysis of 6 RCTs found just 3.45 mmHg systolic reduction — roughly half the effect of a low-dose ACE inhibitor.

    ❌ Plaque reduction: The headline 36% plaque reduction comes from a single retrospective chart review (Chen 2022) with no control group, no randomization, co-administered confounders, and 5 of 10 authors employed by the supplement manufacturer. Meanwhile, the rigorous double-blind NAPS trial (Hodis 2021, n=265) found zero effect on carotid plaque.

    ❌ Lipid lowering: In randomized trials (Yang 2009, Hsia 2009), nattokinase alone doesn't move lipids. The signal only appears in non-randomized studies — often confounded by red yeast rice, which contains monacolin K (chemically identical to lovastatin).

    📉 The case study: I put "Susan" on high-dose nattokinase for a year. Her arterial age went from 64 to 73. We stopped.

    The lesson: Test. Don't guess. Never start a supplement without a plan to stop it if the numbers don't move.

    ⏱️ Chapters
    0:00 Why I stopped using nattokinase
    0:21 Meet Susan
    1:46 What nattokinase actually is
    2:14 How nattokinase works
    5:00 Does it survive digestion?
    6:14 The real signal: blood pressure
    8:34 The plaque-regression claim
    9:59 Problems with the 2022 study
    13:09 The 2017 plaque study
    14:50 The 36% plaque reduction problem
    16:30 Does it lower ApoB or LDL?
    19:31 Why plaque ultrasound is tricky
    22:56 Safety and bleeding concerns
    25:57 What’s actually in the bottle?
    27:24 The NAPS trial
    28:48 Was the dose too low?
    30:29 Susan’s one-year follow-up
    32:51 What if you take it anyway?
    33:42 Final take: test, don’t guess

    ⚠️ This video is for education only and is not personal medical advice. Please talk with your own physician before starting or stopping any supplement or medication — especially if you take aspirin, clopidogrel, warfarin, Eliquis, Xarelto, Pradaxa, or any other blood thinner.

    — PRODUCT POTENCY TESTING —
    Natural Informant (Danny Curtin). "Nattokinase: We Tested Them All… Which Products Can You Trust?" https://youtu.be/K1l_g6-vdC4?si=h4oOnGEw_Vvh51cx

    Sign up for more information on my own practice here: https://corsighthealth.com/

    High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start

    Other tools for optimal health (note these are affiliate links):
    Home BP Cuff: https://amzn.to/49Cq7rh
    Sonicare Toothbrush: https://amzn.to/3KllfMS
    WaterPik: https://amzn.to/4894Xi8
    Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d
    Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS
    Intake Breathing Nasal Support: https://amzn.to/48dfQQ1
    Personal Blender: https://amzn.to/4pyNGGl
    True Nutrition Protein: https://oken.do/q2xzqeqw
    Glass Meal Prep Containers: https://amzn.to/4ocEPJ2
    Sleep Mask: https://amzn.to/48fSJV5
    Air Purifier: https://amzn.to/4puzTQZ

    ___________________________
    🧬 About Dr. Lily Johnston

    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota
    続きを読む 一部表示
    36 分
  • Can You Take Too Much Vitamin K2? Vascular Surgeon Explains

    Can You Take Too Much Vitamin K2? Vascular Surgeon Explains
    2026/06/22

    Can you take too much vitamin K2? In this video, I answer the most common follow-up questions about vitamin K2, including dose, safety, testing, interactions, and whether more is actually better.

    Here's the original video on the K2 clinical trial: https://youtu.be/ArxAXtzsue4

    We’ll cover:
    * Whether vitamin K2 toxicity is possible
    * Whether using MK7 to slow coronary artery calcification is desirable
    * What we know — and do not know — about upper dosing limits
    * Who should be especially cautious with vitamin K supplements
    * Why warfarin/Coumadin changes the conversation
    * Whether vitamin K2 levels can be tested
    * The difference between MK-4 and MK-7
    * Whether vitamin K2 can “remove” calcium from arteries
    * How I think about vitamin K2 in real-world cardiovascular prevention

    The bottom line: vitamin K2 looks promising, but “promising” is not the same thing as “take as much as possible and hope your arteries applaud.”

    This video is for education only and is not personal medical advice. Do not start, stop, or change supplements or medications based on YouTube — especially if you take warfarin or another medication affected by vitamin K. Talk with your own clinician.

    ⏰ Chapters
    0:00 - More of your vitamin K2 questions
    0:22 - Is softer plaque more dangerous than calcified plaque?
    2:35 - Should people with high CAC avoid vitamin D3?
    4:13 - Didn’t the AVADEC trial already show K2 works?
    6:25 - Would a higher dose of K2 work better?
    7:33 - Does K2 actively stop calcium from entering plaque?
    8:28 - Can too much vitamin K2 cause blood clots?
    8:55 - Vitamin K2 and warfarin/Coumadin
    9:48 - Is K2 safe with Eliquis or Xarelto?
    10:23 - Is 100 mcg enough—or should you take more?
    11:16 - Can vitamin K2 remove calcium from arteries?
    11:53 - Can you test for vitamin K deficiency?
    12:37 - MK-4 vs MK-7: which form is better?
    13:25 - Food sources vs K2 supplements
    14:33 - Should K2 be taken with vitamin D3?
    14:58 - Final takeaways

    High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start

    Sign up for more information on my own practice here: https://corsighthealth.com/

    Other tools for optimal health (note these are affiliate links):
    Home BP Cuff: https://amzn.to/49Cq7rh
    Sonicare Toothbrush: https://amzn.to/3KllfMS
    WaterPik: https://amzn.to/4894Xi8
    Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d
    Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS
    Intake Breathing Nasal Support: https://amzn.to/48dfQQ1
    Personal Blender: https://amzn.to/4pyNGGl
    True Nutrition Protein: https://oken.do/q2xzqeqw
    Glass Meal Prep Containers: https://amzn.to/4ocEPJ2
    Sleep Mask: https://amzn.to/48fSJV5
    Air Purifier: https://amzn.to/4puzTQZ

    ___________________________
    🧬 About Dr. Lily Johnston

    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota
    続きを読む 一部表示
    15 分
adbl_web_anon_alc_button_suppression_t1
まだレビューはありません